By F Benedetti; Christoph Stein; et al

ISBN-10: 3540338225

ISBN-13: 9783540338222

ISBN-10: 3540338233

ISBN-13: 9783540338239

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Example text

9 Side Effects . . . . Acute Opioid Application Cardiovascular System . Respiratory System . . Sedation . . . . . Nausea and Vomiting . Cough Suppression . . Pupil Constriction . . Skeletal Muscle Rigidity . Gastrointestinal System . Histamine Release . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

49 49 49 49 50 50 51 51 51 52 52 . . . . . . . . . . . . . . . . . . . . . 32 C. Zöllner · C. 2 Chronic Opioid Application . . . . . . . . . . . . . . 1 Tolerance . . . . . . . . . . . . . . . . . . . 2 Physical Dependence . . . . . . . . . . .

Opening of mitochondrial KATP channels is thought to be protective by preservation of mitochondrial integrity, by dissipation of mitochondrial membrane potential, and consequent reduction of calcium overload and apoptotic cell death (Cao et al. 2005; Cao et al. 2003). In isolated cardiomyocytes as well as sympathectomized intact rat hearts, it was suggested that opioid receptors functionally and physically crosstalk with β-adrenergic receptors, including heterodimerization of these receptors, counterbalance of functionally opposing G protein signaling, and interference with downstream signaling events.

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Analgesia by F Benedetti; Christoph Stein; et al


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