By Krystyna E. Wisniewski, Joseph S. Jeret (auth.), Maryse Lassonde, Malcolm A. Jeeves (eds.)
This booklet is dedicated to the outline of agenesis of the corpus callosum, a congenital malformation of midline buildings within the mind that could be considered as a typical version of the "split-brain. " First suggested by means of Rei! in 1812, this anomaly has considering been defined via a number of investigators. curiosity during this malformation used to be revived within the Seventies by way of reports of interhemispheric move in Bogen and Vogel's commissurotomized sufferers and the following findings by way of Sperry that acallosal sufferers have been without the common disconnection deficits present in sufferers with surgical transection of the corpus callosum. for the reason that this seminal paintings, the majority of neuropsychological learn on callosal agenesis has interested by the details of interhemispheric move and integration. An ever-growing literature has emerged at the topic, trying to specify the level and bounds of neural plasticity in a fearful procedure that has advanced within the absence of crucial interhemispheric pathway. when callosal agenesis proves to be a good version of cerebral plasticity, it should be mentioned that this anomaly is frequently linked to different malformations and neurological illnesses which may bring about varied levels of psychological retardation or different cognitive and sensorimotor deficits. during this context, neurological learn on callosal agenesis has focused on the outline of assorted syndromes linked to this pathology in addition to at the try to specify its neurobehavioral manifestations.
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Extra resources for Callosal Agenesis: A Natural Split Brain?
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A few ovoids of Wallerian degeneration were seen in the nerves of the three youngest patients and in one older patient. In five biopsies there were a few large fibers with a star shaped or crumpled outline suggestive of axonal collapse. Isolated axons with diameters beyond the upper range of normal, but with an abnormally thin sheath were seen in two biopsies. Electron microscopy of one such axon disclosed decreased packing density of neurofilaments. All biopsies showed some focal clusters of small myelinated fibers indicative of axonal regeneration.
Callosal Agenesis: A Natural Split Brain? by Krystyna E. Wisniewski, Joseph S. Jeret (auth.), Maryse Lassonde, Malcolm A. Jeeves (eds.)