By P.A. Voûte, Ann Barrett, Michael C.G. Stevens, Hubert N. Caron

ISBN-10: 0198529325

ISBN-13: 9780198529323

"Cancer in little ones" introduces paediatric oncology in a transparent and concise method, protecting all of the attainable problems which may come up in the course of therapy and a number of the results of the disease. even supposing formative years melanoma is uncommon, accounting for only 1% of all melanoma in industrialized nations, it really is considered one of nice clinical curiosity for a couple of purposes. different types of melanoma are almost designated to youth, while the carcinomas most often visible in adults are super infrequent between young children. the most outstanding development in melanoma therapy has been made in paediatric oncology. research of youth tumours has resulted in significant advances within the knowing of the genetic aetiology of melanoma. "Cancer in youngsters" brings jointly a world crew of hugely revered editors and members who offer evidence-based info on tips on how to examine and deal with the typical cancers in formative years. state-of-the-art descriptions of what's easy and crucial for administration are incorporated; there are new chapters masking destiny tendencies in melanoma chemotherapy, surgical procedure, palliative care, myeloid leukaemia, and malignant mesenchymal tumours; new editors, and lots of new members. aimed toward paediatric oncologists, trainees in oncology and paediatrics, this booklet also will entice paediatric nurses, melanoma nurses, and paramedical paediatric employees.

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Extra info for Cancer in Children: Clinical Management (Oxford Medical Publications)

Example text

This implies that the combination of genes that causes the primary tumour also determines whether the tumour is metastatic or not, and that metastatic capacity may not represent a discrete step in malignant progression. Is there a fundamental difference between paediatric and adult cancer? It is an open question whether paediatric tumours have an essentially different mechanism of pathogenesis and progression from adult tumours. The emerging picture is that one or more characteristic genetic aberrations are found in each tumour type, but that they represent variations on the same theme.

The same holds for activation of cell cycle genes. The cyclin D1 oncogene is amplified or overexpressed in neuroblastoma, and also in several adult tumours. There are certainly aberrations that are specific for some paediatric tumours, like the EWSâ FLI translocations in Ewing sarcoma and the PAXâ forkhead translocations in rhabdomyosarcoma. However, certain adult tumours also show specific genetic aberrations, and the existence of specific abnormalities in paediatric tumours does not indicate a special biologic characteristic of childhood cancer.

Towards a tailored therapy for each patient: how far in the future? Microarray technology shows great promise in the prediction of response to therapy. By analysing the expression profiles of a large tumour series, it should be possible to establish whether tumours that respond to a specific therapy have a different expression profile from that seen in non-responding tumours. This could ultimately improve the selection of treatment for individual patients. Array technology will be even more promising when combined with treatment protocols which include innovative target drugs that inhibit specific proteins, such as Gleevec.

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Cancer in Children: Clinical Management (Oxford Medical Publications) by P.A. Voûte, Ann Barrett, Michael C.G. Stevens, Hubert N. Caron


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