By Deborah K. Hansen, Barbara D. Abbott

ISBN-10: 1420054376

ISBN-13: 9781420054378

Highlighting newest advances in genetics and biochemistry, the thoroughly revised Third Edition reports the sector from uncomplicated technology, scientific, epidemiological, and regulatory views. Contributions from best opinion leaders within the box collect advancements in molecular embryology and mobile biology as they observe to difficulties in developmental toxicology. It covers checking out of pharmaceutical and environmental brokers and interpretation of developmental toxicology info, highlighting mathematical and statistical concepts, in addition to the consequences of poisonous publicity at the sensible improvement of assorted organs.

The dating among maternal and developmental toxicology is tested, as well as present concepts for learning chemical disposition, metabolism, and placental move. shut awareness is given to the regulatory features of trying out and hazard evaluate. Pre- and postconceptional medical care and genetic elements in medical developmental toxicology also are discussed.

Key subject matters include:

  • the roles of apoptosis and sign transduction pathways in common and irregular development
  • the function of epigenetic alterations in development
  • the position of foodstuff and person susceptibility
  • the application of bioinformatics
  • global and specified gene expression changes

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Extra resources for Developmental Toxicology

Sample text

Twomey C, McCarthy JV. Pathways of apoptosis and importance in development. J Cell Mol Med 2005; 9:345–359. 3. Opferman JT. Apoptosis in the development of the immune system. Cell Death Differ 2008; 15:234–242. 4. Mattson MP. Neuronal life-and-death signaling, apoptosis, and neurodegenerative disorders. Antiox Redox Signaling 2006; 8:1997–2006. 5. Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implication in tissue kinetics. Br J Cancer 1972; 26:239–257.

Twomey C, McCarthy JV. Pathways of apoptosis and importance in development. J Cell Mol Med 2005; 9:345–359. 3. Opferman JT. Apoptosis in the development of the immune system. Cell Death Differ 2008; 15:234–242. 4. Mattson MP. Neuronal life-and-death signaling, apoptosis, and neurodegenerative disorders. Antiox Redox Signaling 2006; 8:1997–2006. 5. Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implication in tissue kinetics. Br J Cancer 1972; 26:239–257.

Defects in regulation of apoptosis in caspase-2-deficient mice. Genes Dev 1998; 12:1304–1314. 127. Kuida K, Zheng TS, Na S, et al. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 1996; 384:368–372. 128. Lakhani SA, Masud A, Kuida K, et al. Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science 2006; 311:847–851. 129. Zheng TS, Hunot S, Kuida K, et al. Caspase knockouts: matters of life and death. Cell Death Differ 1999; 6:1043–1053.

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Developmental Toxicology by Deborah K. Hansen, Barbara D. Abbott


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